This is a very popular antidiabetic/insulin sensitizing drug. Recently we saw metformin lowers testosterone in normal men. I wonder if these are just coincidences, or if this is a pattern developing in oral antidiabetic drugs.

Metabolism 2003 Feb;52(2):230-232

Reduced production rates of testosterone and dihydrotestosterone in healthy men treated with rosiglitazone.

Vierhapper H, Nowotny P, Waldhausl W.

Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, Vienna, Austria.

The effect of the thiazolidinedione, rosiglitazone (8 mg/d for 7 days), on the production rates of testosterone (T), dihydrotestosterone (DHT), and cortisol (F) was studied in healthy men (n = 10) using the stable isotope dilution technique and mass spectrometry. Treatment with rosiglitazone resulted in a decrease in the production rates of T from, basal, 318 +/- 62 &mgr;g/h to 272 +/- 72 &mgr;g/h (P <.05). Production rates of DHT fell from, basal, 21 +/- 6 &mgr;g/h to 17 +/- 5 &mgr;g/h (P <.05). Hence, the ratio calcuated from the production rates of T and DHT was unchanged (basal, 17 +/- 7; rosiglitazone, 17 +/- 3). Production rates of cortisol were unchanged (basal, 577 +/- 136 &mgr;g/h; rosiglitazone, 627 +/- 141 &mgr;g/h). These results suggest that a clinically relevant dose of at least one thiazolidindione, rosiglitazone, impedes the production of testosterone in man. Copyright 2003, Elsevier Science (USA). All rights reserved

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Is there something about these meds that causes this, or is it just due to the potentiation of existing slin? If the latter is the case, then wouldn't exSlin use have a similar effect on T levels?


GH and avandia was considered a replacement for GH and slin. I wonder if the end result on T levels would be similar with both treatments.

This study is an interesting one nandi...It was preformed on healthy indivduals. I wonder on what grounds the study was justified, as these drugs are only intended for diabetics. Perhaps avandia was theorized to be a balding treatment or something similar...

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As RB pointed out, are these results significant if you are on cycle anyway? The decrease is statistically significant but not actually that big , only 13%. Which brings up the question of using these drugs post wrokout as a substitute for insulin.

jb

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UP!

RG

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quote:

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, one plus of avandia compared to metformin is , it improved slin sensitivity better compared to metformin

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You could try it during a bulking cycle I suppose. The fat gain is not enormous from the data I have seen. Three or four pounds in type 2 diabetics not using insulin and somewhat more when insulin is used.

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but isn't the old saw that you are born with the numer of fat cells you are going to have, they just get smaller or bigger? This looks to proliferate fat cells increasing the set number.

jb

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